Category Archives: Publications

Enterovirus Epidemiology and Control in Sarawak, Malaysia

Dr. David Perera Director  Institute of Health & Community Medicine, Universiti Malaysia Sarawak, Malaysia ABSTRACT Hand, foot and mouth disease (HFMD) is endemic to Sarawak with outbreaks occurring annually in the state. The disease is primarily caused by Species A enteroviruses which includes enterovirus 71 (EV-A71) and other coxsackievirus A (CVA) serotypes. While the disease is generally presented as a… Read more »

Enterovirus Epidemiology and Control in Malaysia

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Dr. Jamal I-Ching Sam                                          Professor Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Malaysia ABSTRACT Enteroviruses have been the focus of study in Malaysia since 1992 as part of surveillance of acute flaccid paralysis cases. There have been no wild-type polio cases since 1992, while non-polio enteroviruses such as coxsackieviruses A and B, and enterovirus A71 (EV-A71) have… Read more »

Molecular Epidemiology of Human Enterovirus 71 at The Origin of An Epidemic of Fatal Hand, Foot and Mouth Disease Cases in Cambodia

Dr. Veasna Duong Deputy Head, Virology Unit Team, Institut Pasteur du Combodge, Cambodia ABSTRACT Human enterovirus 71 (EV-A71) causes Hand, Foot, and Mouth Disease (HFMD). EV-A71 circulates in many countries, causing large epidemics especially in the Asia-Pacific region since 1997. In April 2012, an undiagnosed fatal disease with neurological involvement and respiratory distress occurred in young children admitted to the… Read more »

Enterovirus Surveillance and Control in Vietnam

Speaker: Dr. Vu Thi Que Huong Senior Researcher, Department of Microbiology and Immunology, Pasteur Institute in HCMC, Vietnam ABSTRACT Hand, foot and mouth disease (HFMD) being a common contagious disease in children, is normally mild, self-recovering but sometimes develops the life–threatening manifestations. It’s mainly caused by enteroviruses, particularly Coxsackieviruses (CA) and Enterovirus71 (EV-A71). HFMD caused by EV-A71 has been reported… Read more »

Surveillance & Control of Enterovirus in Taiwan

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Speaker: Dr. Chin-Hui, Yang (楊靖慧) Division Director Division of Acute Infectious Diseases, Centers for Disease Control, Taiwan ABSTRACT Enterovirus belongs to a group of small RNA viruses, including polioviruses, Coxsackie A viruses, Coxsackie B viruses, etc. Enterovirus type 71(EV71) has a significantly higher pathogenicity compared to other known enteroviruses, especially regarding neurological complications. An unprecedented outbreak of EV71 infections occurred… Read more »

Reemergence of Enterovirus 71 Epidemic in Northern Taiwan, 2012

Shu-Ting Luo, Pai-Shan Chiang, Wan-Yu Chung , Min-Yuan Chia, Kuo-Chien Tsao, Ying-Hsiang Wang, Tzou-Yien Lin, Min-Shi Lee Article Published by POLS ONE on March 16, 2015 Background Enterovirus 71 (EV71) belongs to picornavirus family and could be classified phylogeneti- cally into three major genogroups (A, B and C) including 11 genotypes (A, B1-B5 and C1- C5). Since 1997, EV71 has… Read more »

Enterovirus 71 Maternal Antibodies in Infants,Taiwan

Shu-Ting Luo, Pai-Shan Chiang, An-Shine Chao, Guan-Yuan Liou, Reyin Lin, Tzou-Yien Lin, and Min-Shi Lee Article Published by the Emerging Infectious Diseases on April 2009 Enterovirus 71 (EV71) causes life-threatening disease outbreaks in young children in Asia. This cohort study was conducted to understand the dynamics of maternal EV71 antibodies in Taiwanese young infants. Approximately 50% of neonates had detectable… Read more »

Development of a high-throughput assay for measuring serum neutralizing antibody against enterovirus 71

Mei-Liang Huang, Pai-Shan Chiang, Shu-Ting Luo, Guan-Yuan Liou, Min-Shi Lee Article Published by ELSEVIER on December 29, 2009 Enterovirus 71 (EV71) is the main etiologic agent of hand, foot, and mouth disease (HFMD) and causes frequently severe neurological complications and mortality in young children. The serum neutralizing antibody response is the major indicator of EV71 infection and protective immunity. The… Read more »

An Investigation of Epidemic Enterovirus 71 Infection in Taiwan, 2008

Min-Shi Lee, Tzou-Yien Lin, Pai-Shan Chiang, Wen-Chen Li, Shu-Ting Luo, Kuo-Chien Tsao, Guan-Yuan Liou, Mei-Liang Huang, Shao-Hsuan Hsia, Yhu-Chering Huang, and Shih-Cheng Chang Article Published by the Pediatric Infectious Disease Journal on November 2010 Background: Enterovirus 71 (EV71) is causing life-threatening hand-foot- mouth disease in Asia. In Taiwan, EV71 epidemics with different predom- inant genotypes occurred in 1998 (C2), 2000… Read more »

Incidence Rates of Enterovirus 71 Infections in Young Children during a Nationwide Epidemic in Taiwan, 2008–09

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Min-Shi Lee1, Pai-Shan Chiang, Shu-Ting Luo, Mei-Liang Huang, Guan-Yuan Liou, Kuo-Chien Tsao, Tzou-Yien Lin Article Published by POLS Neglected Tropical Disease on February 14, 2012 Objective: Enterovirus 71 (EV71) is causing life-threatening outbreaks in tropical Asia. In Taiwan and other tropical Asian countries, although nationwide EV71 epidemics occur cyclically, age-specific incidence rates of EV71 infections that are critical to estimate… Read more »