Author Archives: yychen

Enterovirus 71 Maternal Antibodies in Infants,Taiwan

Shu-Ting Luo, Pai-Shan Chiang, An-Shine Chao, Guan-Yuan Liou, Reyin Lin, Tzou-Yien Lin, and Min-Shi Lee Article Published by the Emerging Infectious Diseases on April 2009 Enterovirus 71 (EV71) causes life-threatening disease outbreaks in young children in Asia. This cohort study was conducted to understand the dynamics of maternal EV71 antibodies in Taiwanese young infants. Approximately 50% of neonates had detectable… Read more »

Development of a high-throughput assay for measuring serum neutralizing antibody against enterovirus 71

Mei-Liang Huang, Pai-Shan Chiang, Shu-Ting Luo, Guan-Yuan Liou, Min-Shi Lee Article Published by ELSEVIER on December 29, 2009 Enterovirus 71 (EV71) is the main etiologic agent of hand, foot, and mouth disease (HFMD) and causes frequently severe neurological complications and mortality in young children. The serum neutralizing antibody response is the major indicator of EV71 infection and protective immunity. The… Read more »

An Investigation of Epidemic Enterovirus 71 Infection in Taiwan, 2008

Min-Shi Lee, Tzou-Yien Lin, Pai-Shan Chiang, Wen-Chen Li, Shu-Ting Luo, Kuo-Chien Tsao, Guan-Yuan Liou, Mei-Liang Huang, Shao-Hsuan Hsia, Yhu-Chering Huang, and Shih-Cheng Chang Article Published by the Pediatric Infectious Disease Journal on November 2010 Background: Enterovirus 71 (EV71) is causing life-threatening hand-foot- mouth disease in Asia. In Taiwan, EV71 epidemics with different predom- inant genotypes occurred in 1998 (C2), 2000… Read more »

Incidence Rates of Enterovirus 71 Infections in Young Children during a Nationwide Epidemic in Taiwan, 2008–09

      Comments Off on Incidence Rates of Enterovirus 71 Infections in Young Children during a Nationwide Epidemic in Taiwan, 2008–09

Min-Shi Lee1, Pai-Shan Chiang, Shu-Ting Luo, Mei-Liang Huang, Guan-Yuan Liou, Kuo-Chien Tsao, Tzou-Yien Lin Article Published by POLS Neglected Tropical Disease on February 14, 2012 Objective: Enterovirus 71 (EV71) is causing life-threatening outbreaks in tropical Asia. In Taiwan and other tropical Asian countries, although nationwide EV71 epidemics occur cyclically, age-specific incidence rates of EV71 infections that are critical to estimate… Read more »

Comparing Molecular Methods for Early Detection and Serotyping of Enteroviruses in Throat Swabs of Pediatric Patients

Article published by POLS ONE on October 25,2012 ABSTRACT Background: Enteroviruses include over 100 serotypes and usually cause self-limited infections with non-specific symptoms in children, with the exceptions of polioviruses and enterovirus 71 which frequently cause neurologic complications. Therefore, early detection and serotyping of enteroviruses are critical in clinical management and disease surveillance. Traditional methods for detection and serotyping of… Read more »

Cross-reactive Neutralizing Antibody Responses to Enterovirus 71 Infections in Young Children: Implications for Vaccine Development

Article published by POLS ONE on February 14, 2013 Background: Recently, enterovirus 71 (EV71) has caused life-threatening outbreaks involving neurological and cardiopulmonary complications in Asian children with unknown mechanism. EV71 has one single serotype but can be phylogenetically classified into 3 main genogroups (A, B and C) and 11 genotypes (A, B1,B5 and C1,C5). In Taiwan, nationwide EV71 epidemics with… Read more »

Genetic and Antigenic Characterization of Enterovirus 71 in Ho Chi Minh City, Vietnam, 2011

      Comments Off on Genetic and Antigenic Characterization of Enterovirus 71 in Ho Chi Minh City, Vietnam, 2011

Le Phan Kim Thoa, Pai-Shan Chiang, Truong Huu Khanh, Shu-Ting Luo, Tran Ngoc Hanh Dan, YaFang Wang, Tang Chi Thuong, Wan-Yu Chung, Nguyen Thanh Hung, Jen-Ren Wang, Le Nguyen Thanh Nhan, Le Quoc Thinh, Ih-Jen Su, Than Duc Dung, Min-Shi Lee Article Published by POLS ONE on July 19, 2013 Enterovirus 71 (EV71) frequently causes fatal infections in young children… Read more »

Epidemiology of Enterovirus 71 Infections in Taiwan

Min-Yuan Chia, Pai-Shan Chiang, Wan-Yu Chung, Shu-Ting Luo, Min-Shi Lee Article Accepted by ELSEVIER on July 17, 2013 Enterovirus 71 (EV71) was first described in USA in 1969 but retrospective studies in The Netherlands further detected EV71 in the clinical specimens collected in 1963. EV71 has one single serotype measured by using hyperimmune animal antisera but can be phylogenetically classified… Read more »

CODEHOP-based RT-PCR (VP1- CODEHOP) for enterovirus infections detection and serotyping

      Comments Off on CODEHOP-based RT-PCR (VP1- CODEHOP) for enterovirus infections detection and serotyping

Article Published by POLS ONE on December 1, 2016 ABSTRACT Traditional methods for detection and serotyping of enterovirus infections are virus isolation and immunofluorescence assay (VI-IFA), which are labor-intensive and time-consuming. Recently, VP1 gene has been targeted to develop a CODEHOP-based RT-PCR (VP1- CODEHOP) for the same purpose. In this study, we conducted a 5-year enterovirus surveil- lance comparing the… Read more »

As enterovirus activity peaks, public advised to wash hands with soap and water frequently and watch for prodromal signs of complications in children with enterovirus infection

Press released by CDC, Taiwan Date: July 25, 2017 As enterovirus activity in Taiwan gradually peaks, during July 16 and 22,2017, the number of visits to outpatient services and ER for enterovirus infection in the nation exceeded the epidemic threshold, indicating enterovirus activity has reached its peak. In addition, one new case of enterovirus infection with severe complications was confirmed. Currently,… Read more »