Enteroviruses (EV), the major pathogens of hand, foot, and mouth disease (HFMD) and herpangina, affectmillions of children each year. Most human enteroviruses cause self-limited infections except polio-viruses, enterovirus A71 (EV-A71), enterovirus D68 (EV-D68), and several echoviruses (Echo) and cox-sackieviruses (CV). Especially, EV-A71 has repeatedly caused large-scale outbreaks in the Asia-Pacificregion since 1997. Some Asian countries have experienced cyclical outbreaks of severe EV-A71 infectionsand initiated development of EV-A71 vaccines. Five EV-A71 vaccine candidates have been clinically eval-uated and three of them were approved for marketing in China.