Reemergence of Enterovirus 71 Epidemic in Northern Taiwan, 2012

Shu-Ting Luo, Pai-Shan Chiang, Wan-Yu Chung , Min-Yuan Chia, Kuo-Chien Tsao, Ying-Hsiang Wang, Tzou-Yien Lin, Min-Shi Lee

Article Published by POLS ONE on March 16, 2015


Enterovirus 71 (EV71) belongs to picornavirus family and could be classified phylogeneti- cally into three major genogroups (A, B and C) including 11 genotypes (A, B1-B5 and C1- C5). Since 1997, EV71 has caused large-scale of epidemics with neurological complications in Asian children. In Taiwan, nationwide EV71 epidemics with different predominant genotypes have occurred cyclically since 1998. A nationwide EV71 epidemic occurred again in 2012. We conducted genetic and antigenic characterizations of the 2012 epidemic.


Chang Gung Memorial Hospital (CGMH) is a medical center in northern Taiwan. In CGMH, specimens were collected from pediatric inpatients with suspected enterovirus infections for virus isolation. Enterovirus isolates were serotyped and genotyped and sera from EV71 inpatients were collected for measuring neutralizing antibody titers.


There were 10, 16 and 99 EV71 inpatients identified in 2010, 2011 and 2012, respectively. There were 82 EV71 isolates genotyped, which identified 17 genotype C4a viruses and 65 genotype B5 viruses. The genotype B5 viruses were not detected until November 2011 and caused epidemics in 2012. Interestingly, the B5-2011 viruses were genetically distinguish- able from the B5 viruses causing the 2008 epidemic and are likely introduced from China or Southeastern Asia. Based on antigenic analysis, minor antigenic variations were detected among the B5-2008, B5-2011, C4a-2008 and C4a-2012 viruses but these viruses antigeni- cally differed from genotype A.

10Reemergence of Enterovirus 71 Epidemic in Northern Taiwan, 2012

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